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Aims: To improve our understanding of the pharmacology of 'ecstasy' in recreational environments; in particular, to describe the composition of ecstasy pills, patterns of ecstasy use and the relationship between dose of 3,4-methylendioxymethamphetamine MDMA and resulting plasma concentrations. De, setting and participants: A naturalistic observational study of 56 experienced 'ecstasy' users in recreational settings in Australia. Measurements: Drug use patterns of pills consumed, other drugs consumed.
The dose of MDMA per pill ranged from 0 to mg and users consumed from one-half to five pills, with the total dose consumed ranging up to mg. Use of larger s of pills was associated with extended exposure to the drug. Conclusions: MDMA is the major active drug in ecstasy pills, but there is a high degree of variation in doses. Use of multiple pills over the course of one session is common and in a sustained increase in MDMA plasma concentrations over a of hours.
This is likely to lead to a much greater exposure of the brain to MDMA than would be predicted from controlled single-dose pharmacokinetic studies. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable.
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of items displayed: 5 10 15 20 50 Create RSS Cancel. RSS Link Copy. Full text links Cite Display options Display options. Abstract Aims: To improve our understanding of the pharmacology of 'ecstasy' in recreational environments; in particular, to describe the composition of ecstasy pills, patterns of ecstasy use and the relationship between dose of 3,4-methylendioxymethamphetamine MDMA and resulting plasma concentrations. Laloup M, et al. Forensic Sci Int. Impact of a transient instability of the ecstasy market on health concerns and drug use patterns in The Netherlands.
Brunt TM, et al. Int J Drug Policy. Epub Jul 8. PMID: Dancing hot on Ecstasy: physical activity and thermal comfort ratings are associated with the memory and other psychobiological problems reported by recreational MDMA users. Parrott AC, et al. Hum Psychopharmacol. MDMA, cortisol, and heightened stress What is a normal dose of molly recreational ecstasy users. Behav Pharmacol. PMID: Review. Mood, cognition and serotonin transporter availability in current and former ecstasy MDMA users: the longitudinal perspective.
Thomasius R, et al. J Psychopharmacol. See all similar articles. Cited by 15 articles Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies. Costa G, et al. Neural Regen Res.
Shokry IM, et al. Ann Forensic Res Anal. Epub Nov Effects of MDMA on body temperature in humans. Liechti ME. Temperature Austin. Deaths from exposure to paramethoxymethamphetamine in Alberta and British Columbia, Canada: a case series. Nicol JJ, et al. CMAJ Open. MDMA effects consistent across laboratories. Kirkpatrick MG, et al. Psychopharmacology Berl. Epub Mar See all "Cited by" articles. Publication types Research Support, Non-U. Gov't Actions. MeSH terms Adult Actions. Australia Actions. Chemistry, Pharmaceutical Actions.
Chromatography, Gas Actions. Dose-Response Relationship, Drug Actions. Enzyme-Linked Immunosorbent Assay Actions. Female Actions. Humans Actions. Male Actions. Mass Spectrometry Actions. Risk Factors Actions. Tablets Actions. Time Factors Actions. Young Adult Actions. Substances Hallucinogens Actions. N-Methyl-3,4-methylenedioxyamphetamine Actions. Full text links [x] Wiley. Copy Download.What is a normal dose of molly
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Dosing for pleasure and why less is often more